Microwave assisted Petasis boronic-Manni

We have used a design of experiments （DOE） approach to optimise rapidly a set of microwave

assisted conditions for the Petasis reaction. The optimal conditions involved the microwave

heating of the reaction components in dichloromethane （1M concentration） at120℃ for

10 min in a focussed microwave （CEM Explorer）. These conditions were successfully applied

to a range of Petasis reactions employing either glyoxylic acid or salicylaldehyde as the carbonyl

component along with a number of aryl/heteroaryl boronic acids and amine components.