客户咨询热线:
Data download资料下载
首页>资料下载> Microwave assisted Petasis boronic-Manni

Microwave assisted Petasis boronic-Manni

  发布时间:2009/3/11 点击量: 1774

We have used a design of experiments (DOE) approach to optimise rapidly a set of microwave

assisted conditions for the Petasis reaction. The optimal conditions involved the microwave

heating of the reaction components in dichloromethane (1M concentration) at120℃ for

10 min in a focussed microwave (CEM Explorer). These conditions were successfully applied

to a range of Petasis reactions employing either glyoxylic acid or salicylaldehyde as the carbonyl

component along with a number of aryl/heteroaryl boronic acids and amine components.

Baidu
map