应用微波辐射合成14-Helicalβ-Peptides

Abstract:


We have evaluated the effects of microwave irradiation on the solid-phase synthesis of B-peptides.

Sequences designed to adopt the 14-helix, especially those containing the structure – promoting

residue trans-2-aminocyclohexanecarboxylix acid （ACHC）, suffer from poor synthetic efficiency

under standard SPPS conditions. A comparision of microwave and conventional heating shows

that both provide excellent synthetic results for shorter sequences; however, we identify a clear

benefit from microwave irradiation for longer B-peptides.


应用微波辐射合成14-Helicalβ-Peptides




摘要：


我们已经评估微波辐射对固相合成B-peptides的影响。在标准SPPS条件下, 序列用作吸纳14-螺旋（14- Helix）是存在非常低的合成效率，尤其是那些含有trans-2-aminocyclohexanecarboxylix acid （ACHC） 残余物的结构。比较微波加热和常规加热表明，两者都能为合成短序列多肽提供的综合成果;但是，我们确定微波辐射也能够为合成较长的乙肽（β- Peptides） 提供的综合成果。

微波合成

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